Cerebral oxygenation and brain activity after perinatal asphyxia: does hypothermia change their prognostic value? Pediatr Res. Lemmers PM, Zwanenburg RJ, Benders MJ, de Vries LS, Groenendaal F, van Bel F, et al. A combined brain amplitude integrated electroencephalography and near infrared spectroscopy study. Early predictors of short term neurodevelopmental outcome in asphyxiated cooled infants. 2012 13:267–78.Īncora G, Maranella E, Grandi S, Sbravati F, Coccolini E, Savini S, et al. Neuroprotective mechanisms of hypothermia in brain ischaemia. Cerebral oxygenation and electrical activity after birth asphyxia: their relation to outcome. Toet MC, Lemmers PM, van Schelven LJ, van Bel F. Vasoparalysis associated with brain damage in asphyxiated term infants. Pryds O, Greisen G, Lou H, Friis-Hansen B. Advances in near-infrared spectroscopy to study the brain of the preterm and term neonate. Monitoring and management of brain hemodynamics and oxygenation. Outcomes in childhood following therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy (HIE). Cooling for newborns with hypoxic ischaemic encephalopathy. Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG. Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy. ConclusionĬlinically applied NIRS during TH and rewarming can assist in identifying the risk for brain injury. The area under the ROC curve showed an excellent discrimination for GM involvement. ResultsĬrSO 2 increased significantly from the first to the second day of TH in infants with brain injury, whereas it remained stable in patients with normal MRI. Increasing mean CrSO 2 values during rewarming was associated with brain injury (aOR 1.14 95% CI 1.00–1.28), specifically with gray matter (GM) injury (aOR 1.23 95% CI 1.02–1.49). Of those, 26 presented with brain injury assessed by a novel MRI grading system, whereas 23 had normal MRI scans. This retrospective cohort study included 49 infants, who received TH for mild to severe neonatal encephalopathy. ![]() To assess the association of cerebral oxygen saturation (CrSO 2) collected by near infrared spectroscopy (NIRS) during therapeutic hypothermia (TH) and rewarming with evidence of brain injury on post-rewarming MRI.
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